Zofran (ondansetron) is a medication used to prevent and treat nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also used to prevent postoperative nausea and vomiting (PONV). Zofran works by blocking the effects of serotonin, a neurotransmitter that triggers nausea and vomiting.
Zofran injection is a clear, colorless solution that is given intravenously (IV) or intramuscularly (IM). The usual dose for adults is 8 mg given as a single injection 30 minutes before the start of chemotherapy or radiation therapy. For PONV, the usual dose is 4 mg given as a single injection 30 minutes before surgery.
The most common side effects of Zofran injection include:
These side effects are usually mild and go away within a few days. However, if any side effects are severe or persistent, it is important to contact a doctor.
Zofran injection should be used with caution in patients with:
Zofran injection should not be used by patients who are allergic to ondansetron or any of the other ingredients in the medication.
Zofran injection can interact with several other medications, including:
It is important to tell your doctor about all of the medications you are taking before starting Zofran injection.
Patients receiving Zofran injection should be monitored for side effects, especially QT prolongation. QT prolongation is a rare but serious condition that can lead to heart problems. If QT prolongation occurs, Zofran injection should be stopped and the patient should be evaluated by a doctor.
Zofran injection should be stored at room temperature (20°C to 25°C). Do not freeze or refrigerate. Protect from light.
Indication | Dose |
---|---|
Chemotherapy-induced nausea and vomiting | 8 mg IV or IM 30 minutes before chemotherapy |
Radiation therapy-induced nausea and vomiting | 8 mg IV or IM 30 minutes before radiation therapy |
Postoperative nausea and vomiting | 4 mg IV or IM 30 minutes before surgery |
Side Effect | Incidence |
---|---|
Headache | 10-20% |
Dizziness | 5-10% |
Fatigue | 5-10% |
Constipation | 3-5% |
Diarrhea | 3-5% |
Abdominal pain | 1-3% |
Rash | 1-3% |
Hives | 1-3% |
Flushing | 1-3% |
Palpitations | 1-3% |
Medication | Interaction |
---|---|
Apomorphine | Decreased efficacy of apomorphine |
Benzodiazepines | Increased sedation |
Calcium channel blockers | Increased risk of hypotension |
Carbamazepine | Decreased efficacy of Zofran injection |
Cyclosporine | Increased blood levels of cyclosporine |
Digoxin | Increased blood levels of digoxin |
Erythromycin | Increased blood levels of Zofran injection |
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